Endocrine Abstracts

Inhibins A and B, peptides belonging to TGF-ß superfamily, have an ubiquitous antagonist action on activin signalling. In thyroid gland, TGF-ß1 and activin mainly exert an inhibitory action on growth and function. In human thyroid, beside the presence of activin β subunits and its transductional elements (ActRI/II, SMAD), there is no evidence for α subunit expression, an essential component for inhibin A/B gathering (α-ßA/α-ßB), nor for ...